Liga 2 - Meciurile Etapei 6
| Sep 11, 2021 11:00 | AFC Dunărea 2005 Călăraşi | 1 - 1 | AFC Unirea Constanţa |  |
| Sep 11, 2021 11:00 | AFC 1919 Dacia Unirea Brăila | 0 - 2 | CS Concordia Chiajna | |
| Sep 11, 2021 11:00 | SC Fotbal Club Ripensia Timișoara | 2 - 1 | AFC Astra | |
| Sep 11, 2021 11:00 | CSC 1599 Şelimbăr | 2 - 1 | Fotbal Club Braşov | |
| Sep 11, 2021 13:00 | FC Metaloglobus Bucureşti | 4 - 1 | Politehnica Timișoara | |
| Sep 11, 2021 15:30 | FC Unirea Dej | 2 - 1 | Clubul Sportiv al Armatei Steaua | |
| Sep 12, 2021 11:00 | AFC Unirea 04 Slobozia | 0 - 2 | ACS Petrolul 52 | |
| Sep 12, 2021 13:00 | ACSM Politehnica Iaşi | 0 - 1 | AS Fotbal Club Buzău | |
| Sep 13, 2021 16:00 | AFK Csikszereda Miercurea Ciuc | 3 - 1 | AS FC Universitatea Cluj | |
| Sep 14, 2021 17:00 | ACS Viitorul Pandurii Târgu Jiu | 1 - 1 | AFC Hermannstadt | |
* Clubul AFC Astra a fost sancţionat cu o penalitate de 20 puncte prin deciziile CDE din 16.06.2021, 30.06.2021, 07.07.2021, 14.07.2021, 25.08.2021, 22.09.2021, 22.09.2021 şi 28.01.2022
| Loc | Echipa | M | V | E | I | Gol | +/- | Pct |
| 1. | CS Concordia Chiajna | 6 | 5 | 1 | 0 | 10-1 | 9 | 16 |
| 2. | ACS Petrolul 52 | 6 | 5 | 0 | 1 | 13-1 | 12 | 15 |
| 3. | AFC Hermannstadt | 6 | 4 | 2 | 0 | 12-5 | 7 | 14 |
| 4. | Clubul Sportiv al Armatei Steaua | 6 | 4 | 1 | 1 | 12-5 | 7 | 13 |
| 5. | AS FC Universitatea Cluj | 6 | 4 | 0 | 2 | 8-6 | 2 | 12 |
| 6. | AFC Unirea 04 Slobozia | 6 | 3 | 2 | 1 | 12-4 | 8 | 11 |
| 7. | AS Fotbal Club Buzău | 6 | 3 | 1 | 2 | 20-4 | 16 | 10 |
| 8. | FC Metaloglobus Bucureşti | 6 | 3 | 1 | 2 | 10-7 | 3 | 10 |
| 9. | SC Fotbal Club Ripensia Timișoara | 6 | 2 | 3 | 1 | 8-7 | 1 | 9 |
| 10. | CSC 1599 Şelimbăr | 6 | 3 | 0 | 3 | 6-9 | -3 | 9 |
| 11. | FC Unirea Dej | 6 | 2 | 2 | 2 | 5-4 | 1 | 8 |
| 12. | Politehnica Timișoara | 6 | 2 | 1 | 3 | 7-10 | -3 | 7 |
| 13. | ACSM Politehnica Iaşi | 6 | 2 | 0 | 4 | 4-6 | -2 | 6 |
| 14. | Fotbal Club Braşov | 6 | 1 | 3 | 2 | 5-11 | -6 | 6 |
| 15. | AFC Dunărea 2005 Călăraşi | 6 | 0 | 3 | 3 | 5-11 | -6 | 3 |
| 16. | ACS Viitorul Pandurii Târgu Jiu | 6 | 0 | 3 | 3 | 3-9 | -6 | 3 |
| 17. | AFK Csikszereda Miercurea Ciuc | 6 | 1 | 0 | 5 | 4-12 | -8 | 3 |
| 18. | AFC 1919 Dacia Unirea Brăila | 6 | 0 | 2 | 4 | 4-15 | -11 | 2 |
| 19. | AFC Unirea Constanţa | 6 | 0 | 1 | 5 | 1-22 | -21 | 1 |
| 20. | AFC Astra | 6 | 2 | 2 | 2 | 6-6 | 0 | -12 |