Liga 2 - Meciurile Etapei 5
| Aug 26, 2021 20:00 | Politehnica Timișoara | 0 - 1 | ACSM Politehnica Iaşi |  |
| Aug 28, 2021 11:00 | CSC 1599 Şelimbăr | 1 - 0 | AFC Dunărea 2005 Călăraşi | |
| Aug 28, 2021 11:00 | Fotbal Club Braşov | 1 - 0 | FC Unirea Dej | |
| Aug 28, 2021 11:00 | AFC Astra | 1 - 1 | AFC Unirea 04 Slobozia | |
| Aug 28, 2021 11:00 | AS Fotbal Club Buzău | 14 - 0 | AFC Unirea Constanţa | |
| Aug 28, 2021 12:30 | AS FC Universitatea Cluj | 2 - 1 | FC Metaloglobus Bucureşti | |
| Aug 28, 2021 15:30 | ACS Petrolul 52 | 4 - 0 | AFC 1919 Dacia Unirea Brăila | |
| Aug 29, 2021 12:00 | CS Concordia Chiajna | 0 - 0 | ACS Viitorul Pandurii Târgu Jiu | |
| Aug 29, 2021 14:00 | Clubul Sportiv al Armatei Steaua | 2 - 0 | SC Fotbal Club Ripensia Timișoara | |
| Aug 30, 2021 14:00 | AFC Hermannstadt | 4 - 1 | AFK Csikszereda Miercurea Ciuc | |
* Clubul AFC Astra a fost sancţionat cu o penalitate de 20 puncte prin deciziile CDE din 16.06.2021, 30.06.2021, 07.07.2021, 14.07.2021, 25.08.2021, 22.09.2021, 22.09.2021 şi 28.01.2022
| Loc | Echipa | M | V | E | I | Gol | +/- | Pct |
| 1. | Clubul Sportiv al Armatei Steaua | 5 | 4 | 1 | 0 | 11-3 | 8 | 13 |
| 2. | AFC Hermannstadt | 5 | 4 | 1 | 0 | 11-4 | 7 | 13 |
| 3. | CS Concordia Chiajna | 5 | 4 | 1 | 0 | 8-1 | 7 | 13 |
| 4. | ACS Petrolul 52 | 5 | 4 | 0 | 1 | 11-1 | 10 | 12 |
| 5. | AS FC Universitatea Cluj | 5 | 4 | 0 | 1 | 7-3 | 4 | 12 |
| 6. | AFC Unirea 04 Slobozia | 5 | 3 | 2 | 0 | 12-2 | 10 | 11 |
| 7. | AS Fotbal Club Buzău | 5 | 2 | 1 | 2 | 19-4 | 15 | 7 |
| 8. | Politehnica Timișoara | 5 | 2 | 1 | 2 | 6-6 | 0 | 7 |
| 9. | FC Metaloglobus Bucureşti | 5 | 2 | 1 | 2 | 6-6 | 0 | 7 |
| 10. | SC Fotbal Club Ripensia Timișoara | 5 | 1 | 3 | 1 | 6-6 | 0 | 6 |
| 11. | ACSM Politehnica Iaşi | 5 | 2 | 0 | 3 | 4-5 | -1 | 6 |
| 12. | CSC 1599 Şelimbăr | 5 | 2 | 0 | 3 | 4-8 | -4 | 6 |
| 13. | Fotbal Club Braşov | 5 | 1 | 3 | 1 | 4-9 | -5 | 6 |
| 14. | FC Unirea Dej | 5 | 1 | 2 | 2 | 3-3 | 0 | 5 |
| 15. | AFC Dunărea 2005 Călăraşi | 5 | 0 | 2 | 3 | 4-10 | -6 | 2 |
| 16. | ACS Viitorul Pandurii Târgu Jiu | 5 | 0 | 2 | 3 | 2-8 | -6 | 2 |
| 17. | AFC 1919 Dacia Unirea Brăila | 5 | 0 | 2 | 3 | 4-13 | -9 | 2 |
| 18. | AFK Csikszereda Miercurea Ciuc | 5 | 0 | 0 | 5 | 1-11 | -10 | 0 |
| 19. | AFC Unirea Constanţa | 5 | 0 | 0 | 5 | 0-21 | -21 | 0 |
| 20. | AFC Astra | 5 | 2 | 2 | 1 | 5-4 | 1 | -12 |